Changes in hemodynamics with a combination of epidural anesthesia and propofol sedation in children
Agzamkhodzhaev, T.S.; Tokhirov, S.M.; Kholmukhamedov, B.M.
Anesteziologiia i Reanimatologiia 2002(1): 6-9
2002
ISSN/ISBN: 0201-7563 PMID: 11998392 Document Number: 545878
Hemodynamic profiles and myocardial contractility were investigated in children aged 3-14 years during epidural anesthesia with propofol. Anesthesia was induced by intravenous bolus propofol (3.5 mg/kg). Ketamine (2.4 mg/kg) was used to potentiate analgesia during intubation. Xilocaine (5 mg/kg) was used for epidural analgesia. Anesthesia was maintained by continuous i.v. propofol infused in a dose of 191-312 micrograms/kg x min (mean dose 243 +/- 30.3 micrograms/kg x min) until the peak of epidural analgesic activity was reached, after which propofol dose was gradually reduced to 53-143 micrograms/kg x min (mean 108.8 +/- 14.6 micrograms/kg x min). This variant of epidural anesthesia with i.v. propofol ensured a hemodynamically stable anesthesia and good analgesia in operations of any complexity. It was however paralleled by a moderate decrease of myocardial contractility.