Mechanisms of large artery remodeling
Cwynar, M.; Wojciechowska, W.; Kawecka-Jaszcz, K.; Grodzicki, T.
Przeglad lekarski 59 Suppl. 3: 1-8
2002
ISSN/ISBN: 0033-2240 PMID: 12652989 Document Number: 545692
Degenerative changes of elastin, increase of collagen fibres, proliferation of muscle cells and impairment in endothelium function occurs in the vessel wall with ageing, in hypertensive and others diseases. Early changes are potentially reversible. Atherosclerosis is a late stage of pathologies occurring in the arterial wall in response to various factors. The present paper describes current knowledge on mechanisms of arterial wall remodelling. The authors define basic indices of arterial compliance and describe several physiological and pathological factors which occur play the main role in process of arterial wall remodelling. A chapter is devoted to the effects of increased arterial stiffness on heart pathology and clinical implications of measuring these parameters.