Use of Azopiram for rapid diagnosis of epithelial tumors of the urinary bladder (experimental data)
Pliss, G.B.; Al'-Shurki, S.K.; Mel'nikov, A.S.; Pliss, M.G.
Voprosy Onkologii 48(6): 703-705
2002
ISSN/ISBN: 0507-3758 PMID: 12530268 Document Number: 545086
Correlation of development of tumor pathology and macro- and microhematuria was investigated in the experiments using 50 male rats with N-butyl-N-(4-hydroxybutyl)-nitrosoamine-induced tumors of the urinary bladder. Our highly-sensitive agent Azopiram was employed to monitor hematuria. Microhematuria, which subsequently developed into macrohematuria as tumor matured and turned malignant, was identified as early as at such incipient neoplastic changes as focal hyperplasia of the urothelium and micropapillomatosis. The test can be used outside clinic as a measure of self-control in recurrent cancer of the urinary bladder.