Systemic corticosteroids in rheumatoid arthritis: to use or not to use?
Amano, K.
Nihon Rinsho. Japanese Journal of Clinical Medicine 60(12): 2364-2369
2002
ISSN/ISBN: 0047-1852 PMID: 12510363 Document Number: 542597
Systemic corticosteroids(steroids) were initially introduced after the dramatic efficacy in individual patients with rheumatoid arthritis(RA). Since the outcome of steroid therapy in RA turned to be awesome, steroids had been put at the apex of the therapeutic pyramid for a long time. However, most rheumatologists have subscribed steroids for the treatment of early active RA because they can provide rapid and significant clinical response. Moreover, recent several studies have shown that low dose(5 to 10 mg/day) of prednisolone retard joint destruction in a few years. However, the demonstrated negatives(opportunistic infections, osteoporosis, metabolic disorders, atherosclerotic vascular events etc.) of steroids may outweigh these advantages in the longterm clinical course of RA.