A new classification plot for the C-peptide suppression test
Saddig, C.; Bender, R.; Starke, A.A.R.
Jop Journal of the Pancreas 3(1): 16-25
2002
ISSN/ISBN: 1590-8577 PMID: 11884763 Document Number: 542512
To evaluate the C-peptide suppression test as a screening test in patients with symptoms of hypoglycemia as compared to the standard fasting test. Retrospective discriminant analysis of data from C-peptide suppression tests. Clinical study. Patients with insulinomas and patients without insulinomas but having symptoms compatible with hypoglycemia. The results from C-peptide suppression tests of 26 patients with insulinomas and 100 patients without insulinomas were compared. A classification plot which introduces two discriminant parameters for the C-peptide suppression test: the ratio of ratio (21.9 +/- 14.6 vs. 139.2 +/- 43.8; P<0.001). Discriminant analysis revealed a specificity of 96% to rule out the diagnosis of 'insulinoma' at a 1% probability threshold with a sensitivity of 100%. We developed a new classification plot for the C-peptide suppression test in order to accurately identify those patients whose symptoms of hypoglycemia are not due to endogenous hyperinsulinemia/insulinomas. Thus, the need for fasting tests and hospitalization costs can be reduced.