Sib 1893 possesses pro- and anticonvulsant activity in the electroshock seizure threshold test in mice
Luszczki, J.; Borowicz, K.K.; Czuczwar, S.ła.J.
Polish Journal of Pharmacology 54(5): 517-520
2002
ISSN/ISBN: 1230-6002 PMID: 12593540 Document Number: 541157
SIB 1893, a non-competitive antagonist of group I metabotropic glutamate receptor subtype 5, administered at the doses ranging between 0.5-2 mg/kg markedly lowered the electroconvulsive threshold, whereas if applied at the higher dose of 40 mg/kg, it significantly raised the threshold for electroconvulsions in mice, exhibiting both pro- and anticonvulsive properties in this test.