In vivo study of xibornol on phagocyte functions
Zanon, P.; De Rose, V.; Bersani, C.; Caritinos, P.; Mazzocchi, P.
Chemioterapia International Journal of the Mediterranean Society of ChemoTherapy 3(3): 156-158
1984
ISSN/ISBN: 0392-906X PMID: 6529770 Document Number: 5411
Polymorphonuclear leukocytes (PML) represent the first step of defense against bacteria and fungi. Since many antimicrobial drugs have been reported to inhibit phagocyte function, we tested the interference of xibornol, a new antimicrobial agent, on phagocyte functions, in order to evaluate its possible use in chronic respiratory diseases. In the patients treated with xibornol (500 mg every 8 h for 7 days) we did not find any modification in phagocytosis frequency (PMF), phagocytosis index (PHI), nitroblue tetrazolium (NBT), reduction frequency (NRF), microbicidal activity and neutrophil mobility of PML, before, during and after the end of therapy.
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