A case of nonarteritic ischemic optic neuropathy (NAION) in a male patient taking sildenafil
Boshier, A.; Pambakian, N.; Shakir, S.A.W.
International Journal of Clinical Pharmacology and Therapeutics 40(9): 422-423
2002
ISSN/ISBN: 0946-1965 PMID: 12358159 Document Number: 540928
Sildenafil is a phosphodiesterase-type-5 inhibitor indicated for the treatment of erectile dysfunction in men. We report a case of NAION identified from a cohort of 8,893 patients (from a Prescription-Event Monitoring study) prescribed sildenafil by their primary care physician in England between April and June 1999. This 61-year-old patient had risk factors for NAION independent of drug therapy. It was not possible to be confident about a causal association between sildenafil and NAION, though the possibility could not be ruled out. Epidemiological data suggest that one case of NAION might be expected in a cohort of 8,893 subjects. Thus it remains important for clinicians to consider the range of risk factors for NAION; while equally, the processes of pharmacovigilance need to continue as for any recently launched drug preparation.