Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia
Korbi, S.; Trimeche, M.; Sriha, B.; Yacoubi, M.T.; Hmissa, S.; Mokni, M.; Delvenne, P.; Boniver, J.; Rammeh, S.
Annales de Pathologie 22(2): 96-101
2002
ISSN/ISBN: 0242-6498 PMID: 12124490 Document Number: 540720
The purpose of this study was to evaluate the prevalence of Epstein-Barr virus in Hodgkin disease in Tunisia through a series of 77 cases. Association with Epstein-Barr virus was demonstrated by Epstein-Barr encoded early RNA transcripts (EBER) in situ hybridization in 70% of cases and by latent membrane protein 1 (LMP1) immunohistochemistry in 58.4% of cases. EBER positive cases were more frequent in extreme age classes (<15 and>54 years) there was no correlation with sex, histologic sub-type and clinical stage. Our findings show a high prevalence for EBV infection in Tunisian Hodgkin's disease particularly among extreme ages.