Pseudoallergies
Bernardini, R.; Novembre, E.; Lombardi, E.; Monaco, M.G.; Monte, M.T.; Pucci, N.; Rossi, M.E.; Vierucci, A.
La Pediatria Medica e Chirurgica Medical and Surgical Pediatrics 23(1): 9-16
2001
ISSN/ISBN: 0391-5387 PMID: 11486428 Document Number: 540406
Pseudo-allergic-reactions (PAR) are clinical manifestations including urticaria, angioedema, conjunctivitis, rhinitis, asthma, and anaphylaxis. The prevalence of PAR ranges from 0.1% to 75% according to various studies. The pathogenetic mechanism of these diseases is not immunologically mediated. Food, additives, and drugs are the main responsibilities for PAR. The diagnosis of PAR is characterized by the absence of specific IgE for the suspected products. The absence of immunological mechanisms is confirmed by in vitro and in vivo tests. The treatment of PAR is similar to that of allergic diseases (antihistamine drugs, steroids, B2 agonists, epinephrine).