Squamous cell papilloma of the esophagus: a tumour probably caused by human papilloma virus (HPV)
Syrjänen, K.; Pyrhönen, S.; Aukee, S.; Koskela, E.
Diagnostic Histopathology 5(4): 291-296
1982
ISSN/ISBN: 0272-7749 PMID: 6188592 Document Number: 540
The third well-documented case of an esophageal squamous cell papilloma in the literature is studied by light microscopy and using an indirect immunoperoxidase-peroxidase-antiperoxidase-technique. Human papilloma virus (HPV) antigens were found within the nuclei of the superficial dyskeratotic cells and of koilocytes, both of which are characteristic cells found in HPV lesions elsewhere in the body. The findings are discussed in the light of current concepts of HPV lesions in general. This tumor is potentially malignant and the possible role of HPV in human esophageal carcinogenesis deserves further study.
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