The role of physiologically based toxicokinetic models in biologically based risk assessment
Watanabe, K.H.; Chen, C.
Folia Histochemica et Cytobiologica 39(Suppl 2): 50-51
2001
ISSN/ISBN: 0239-8508 PMID: 11820625 Document Number: 539275
Biologically-based cancer risk assessment relies on mathematical models that represent the toxicokinetics and toxicodynamics of the xenobiotic in the body. Physiologically-based toxicokinetic (PBTK) models are used as a tool for predicting the target tissue dose of a xenobiotic from different routes of exposure, extrapolating from high doses to low doses and extrapolating between species. This paper reviews the role of PBTK models and their limitations in biologically-based risk assessment.