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A comparison of the kinetic characters of NT-3, NT-4 and BDNF retrogradely transported in facial nerve

Li, Y.; Chen, Z.; Wang, Q.; Liang, Z.; Kuang, A.; He, G.; Gao, B.; Lin, D.

Hua Xi Yi Ke da Xue Xue Bao 32(4): 535-537

2001

ISSN/ISBN: 0257-7712
PMID: 12528541
Document Number: 537747
To compare the kinetic characters of retrograde transport of neurotrophin-3 (NT-3), neurotrophin-4 (NT-4) and brain-derived neurotrophin factor (BDNF) in facial nerve. Radioactive tracer technique was used. After one lateral facial nerve trunk of adult rabbit was transected, a silicone chamber was inserted between the stumps, and 3.7 MBq of 125I-NT-3 or 125I-NT-4 or 125I-BDNF or 125I-HSA was administered into the chamber. At different time-points after injection, the facial nerve trunk and facial nerve motor neurone of brain-stem were collected and the uptake rates were measured. The kinetic parameters of each labeled compound were calculated using 3P87 program of kinetics. The transport amount of neurotrophin retrogradely transported by facial nerve is NT-3 > BDNF > NT-4 (P < 0.05), the transport rate is NT-4 > NT-3 > BDNF (P < 0.05). The findings could serve as the kinetic characters of retrograde transport of neurotrophins.

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