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Enhancement of beta-sitosterol transformation in Mycobacterium vaccae with increased cell wall permeability

Korycka-Machała, M.; Rumijowska-Galewicz, A.; Lisowska, K.; Ziolkowskit, A.; Sedlacze, L.

Acta Microbiologica Polonica 50(2): 107-115

2001

ISSN/ISBN: 0137-1320
PMID: 11720305
Document Number: 536437
Mycobacterium vaccae exposed to compounds which are known to disorganise the cell wall composition and architecture (protamine, glycine) showed increased specific activity in beta-sitosterol biotransformation to androstene derivatives, intermediates in the production of most medical steroids. GC/MS analysis of free lipid fatty acids revealed higher content of unsaturated compounds, mainly C16:1 and C18:1 in protamine- and glycine-treated cells than that in control cells, which seems to change the permeability features of the cell wall barrier, facilitating hydrophobic beta-sitosterol diffusion.

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