Acute kidney failure caused by paracetamol poisoning
Herrero, J.L.; Castellano, I.; Gómez-Martino, J.R.; Novillo, R.; Covarsí, A.
Nefrologia Publicacion Oficial de la Sociedad Espanola Nefrologia 21(6): 592-595
2001
ISSN/ISBN: 0211-6995 PMID: 11881430 Document Number: 536024
Paracetamol poisoning is manifested by hepatotoxicity, but acute renal failure is very rare, especially when there is no fulminant hepatic damage with encephalopathy or severe haemodynamic alterations. We present here the case of a 22-year-old woman who presented with acute renal failure after the ingestion of 11.5 g of acetaminophen. The clinical course and laboratory data were consistent with tubular necrosis. The patient required hemodialysis, but finally renal function returned to normal. The acetaminophen pharmacology and the differential diagnosis of acute azotemia in paracetamol overdosage are reviewed.