Studies on the stability of ligustilide with solvent effect
Zhou, C.X.; Li, X.H.
Yao Xue Xue Bao 36(10): 793-795
2001
ISSN/ISBN: 0513-4870 PMID: 12579984 Document Number: 535926
To study the stability of ligustilide with solvent effect and try to disclose the relationship between its stability and solvent effect, so as to develop a useful method for its preservation. The model of PCM solvent effect was used to carry out quantum chemistry calculation. The GC/MS spectrum was used to study the stability of ligustilide in solvent at room temperature. Ligustilide is more stable in cyclohexane and chloroform than in air. The isomerization rate of ligustilide decreased remarkably to 1.6% and 6.7% in cyclohexane and chloroform compared to 58% in air. The stability of ligustilide is greatly improved with the solvent effect. Keeping ligustilide in proper organic solvent is helpful to prevent its isomerization.