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Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba

Suzuki, K.; Yahara, S.; Maehata, K.; Uyeda, M.

Journal of Natural Products 64(2): 204-207

2001

ISSN/ISBN: 0163-3864
PMID: 11430001
Document Number: 535714
A novel inhibitor of topoisomerase I designated as isoaurostatin (1) was isolated from the culture filtrate of Thermomonospora alba strain No. 1520. The structure of 1 was determined to be 6,4'-dihydroxyisoaurone on the basis of spectroscopic (NMR and MS) methods. Compound 1 inhibited the relaxation activity of calf thymus topoisomerase I in a noncompetitive manner and did not inhibit the relaxation and decatenation of human placenta topoisomerase II. Compound 1 is an inhibitor belonging to cleavable complex-nonforming type without DNA intercalation.

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