Hepatic hemangioendothelioma associated with production of humoral thyrotropin-like factor
Ayling, R.M.; Davenport, M.; Hadzic, N.; Metcalfe, R.; Buchanan, C.R.; Howard, E.R.; Mieli-Vergani, G.
Journal of Pediatrics 138(6): 932-935
2001
ISSN/ISBN: 0022-3476 PMID: 11391345 Document Number: 535585
We report on 7 patients referred for treatment of hepatic hemangioendothelioma with increased thyrotropin levels. The serum thyroxine level was decreased in 4 and increased in 2. Immunohistochemistry showed positive staining of tumor, but not of normal liver tissue, for thyrotropin. We propose secretion by the tumor of a thyrotropin-like factor.
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