Serotonin transporter gene polymorphism in families with schizophrenia
Golimbet, V.E.; Shcherbatykh, T.V.; Abramova, L.I.; Kaleda, V.G.; Oleĭchik, I.V.; Orlova, V.A.; Rogaev, E.I.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 101(10): 40-41
2001
ISSN/ISBN: 1997-7298 PMID: 11712269 Document Number: 534874
Recently association between VNTR-17 (12 copies, allel 12) and schizophrenia has been reported. Relations between allele polymorphism of serotonin transporter gene and schizophrenia in 71 Russian families with schizophrenia (n = 253) were studied. Genotyping was made by VNTR-17 and HTTLPR loci. Allele 10 was transmitted 25 times and allele 12 was transmitted 28 times. In the case of HTTLPR polymorphism allele I was transmitted 26 times and allele s was transmitted 19 times. These differences in transmission also were statistically insignificant (p = 0.69). Therefore, our findings do not support association between 5-HTT polymorphism and susceptibility to schizophrenia.