Gastric evacuation time following a standard meal as determined by radio-opaque granules. Clinical applications and validation

Bertrand, J.; Metman, E.H.; Dorval, E.D.; Rouleau, P.; D'Hueppe, A.; Itti, R.; Philippe, L.

Gastroenterologie Clinique et Biologique 4(11): 770-776

1980


ISSN/ISBN: 0399-8320
PMID: 7461389
Document Number: 5338
Qualitative evaluation of gastric emptying can be obtained by incorporating 100 undissolvable radio-opaque granules into a standard meal prior to taking a series of X-rays at fixed intervals. Whereas gastric emptying time varies from one subject to another, reproducible curves are obtained for each subject (P<0.05). The validity of such a method was determined using 20 volunteers by associating a study of the elimination of the granules with a double isotopic labelling of the meal. The evacuation of the granules is better correlated with the elimination of solids (r=0.69) than with liquids (r=0.51). The clinical study involved 167 patients, including 49 controls. For the controls, gastric emptying half-time was an average of 2 h 10 min, and the curve was limai,. The patients studied had various affections including: duodenal ulcer (5 cases), simple diabetes (28 cases), insulin-dependent diabetes (16 cases). Our results generally confirmed those previously published. In primary essential gastric dyspepsia (46 cases) a significant slowing down in gastric emptying is seen (P<0.001) which is strongly indicative of functional gastric stasis. This simple procedure which closely approximates normal physiological conditions, enables quantitative determination of gastric emptying in normal subjects and patients with various pathological conditions.

Document emailed within 1 workday
Secure & encrypted payments

Gastric evacuation time following a standard meal as determined by radio-opaque granules. Clinical applications and validation