Recombinant granulocyte colony-stimulating factor (G-CSF) in infectious diseases: still a debate
Wiedermann, F.J.; Mittermayr, M.; Hoffmann, G.; Schobersberger, W.
Wiener Klinische Wochenschrift 113(3-4): 90-96
2001
ISSN/ISBN: 0043-5325 PMID: 11253746 Document Number: 533291
Granulocyte colony-stimulating factor (G-CSF), a central mediator of the endogenous response to infection and inflammation, is approved for use in the prevention of infection-related complications in patients with nonmyeloid malignancies during antineoplastic therapy associated with high risk of severe neutropenia. Administration of granulocyte colony-stimulating factor results in improvement of host defence paired with anti-inflammatory effects. There is evidence from animal and clinical studies that administration of granulocyte colony-stimulating factor may also be beneficial in non-neutropenic infections. This review focuses mainly on the results of different animal and clinical studies of granulocyte colony stimulating factor used in the treatment of severe infections and sepsis.