Comparative study of the diagnostic value of new cholera eltor bacteriophages ctx+, ctx-, and KhDF-3, 4, and 5
Saiapina, L.V.; Anisimova, T.I.; Adamova, G.V.; Kasina, I.V.; Ostroumova, N.M.; Gracheva, I.V.; Kazakova, E.S.; Livanova, L.F.; Mironova, N.P.; Kudriakova, T.A.; Batyrova, B.A.; Omarova, K.B.; Reznikov, I.B.; Plotnikov, O.P.; Shchelkanova, E.I.; Malakhaeva, A.N.; Korovkina, G.I.; Smirnova, N.I.; Noskov, A.K.; Bushineva, E.A.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 3: 69-72
2001
ISSN/ISBN: 0372-9311 PMID: 11550565 Document Number: 533065
The comparative evaluation of the diagnostic value of new cholera eltor bacteriophages ctx+ and ctx-, as well as monophages X[symbol: see text]-3, 4, 5, demonstrated their high activity and specificity. Using of these bacteriophages epidemic potential of 95% Vibrio cholerae eltor strains ctx+ and 84.5% of V. cholerae eltor stains ctx- was determined. Commercial monophages X[symbol: see text]-3, 4, 5 were inferior to bacteriophages ctx+ and ctx- in their diagnostic value: only 55% of strains having gene ctxAB were found to be epidemically dangerous, i.e. 45% of strains capable of causing the disease were not detected. On the basis of the results obtained in this investigation cholera eltor bacteriophages ctx+ and ctx- were recommended for introduction into practical use, while further production of cholera diagnostic monophages X[symbol: see text]-3, 4, 5 was recommended to be stopped.