Antioxidant effects of vetoron in flying personnel with arterial hypertension
Uspenskiĭ, S.V.; Bobrovnitskiĭ, I.P.; Nagornev, S.N.; Preobrazhenskiĭ, V.N.
Aviakosmicheskaia i Ekologicheskaia Meditsina 35(1): 73-76
2001
ISSN/ISBN: 0233-528X PMID: 11385989 Document Number: 532883
The purpose of the investigation was to assess the possibility to control free radical oxidation in patients with cardiovascular pathologies with the help of vetoron. This was the first attempt to study effects of a beta-carotene (vetoron) on lipid peroxidation and the activity of antioxidant defense enzymes in flying personnel with cardiovascular pathologies (hypertension and neurocirculatory dystonia). Therapeutic effect of the medicament was evaluated by its action on peroxide metabolism (malonic dialdehyde, acyl hydroperoxides and trien conjugates, Schiff bases) and stimulation of the antioxidant defense enzymes (catalase and glutathione reductase). Results of the investigation pointed to the inhibition of lipid peroxidation against activation of the antioxidant defense enzymes in patients with hypertension who had been given the course of vetoron; however, in patients with neurocirculatory dystonia.