Two cases of squamous cell carcinoma of the anal canal treated with chemoradiotherapy
Sasaoka, M.; Fuwa, N.; Matsumoto, A.; Furutani, K.; Kamata, M.; Kodaira, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 28(3): 399-402
2001
ISSN/ISBN: 0385-0684 PMID: 11265413 Document Number: 532812
We recently treated 2 patients with squamous cell carcinoma in the anal canal with bilateral inguinal nodal metastases using chemoradiotherapy. Chemotherapy (CT) consisted of 5-fluorouracil 700 mg/m2/day (continuous intravenously) on days 1-5 and cisplatin 50 mg/m2/day (continuous intravenously) on days 6-7. Chemotherapy was administered before the beginning of radiotherapy. In one patient, 2 cycles of CT were performed, and in the other patient 1 cycle only. The total radiation dose was 57.6 Gy to the primary lesion in each patient, and 53.6 Gy, 55.8 Gy to the nodal metastases, respectively. As a primary treatment response, CR was obtained in both patients. Acute grade 3-4 hematologic toxicities were observed in one patient. The patients have had 7 and 9 months survival without disease, and excellent function of the anal sphincter after treatment.