Primary brain lymphomas
Bojanowski, K.; Kroh, H.; Marchel, A.; Sulejman, W.
Neurologia i Neurochirurgia Polska 35(1): 91-100
2001
ISSN/ISBN: 0028-3843 PMID: 11464720 Document Number: 532769
In the Department of Neurosurgery of the Medical University of Warsaw 11 patients with primary central nervous system lymphomas were diagnosed and treated between 1990 and 1999. The patients comprised of 6 females and 5 males, aged 23 to 86 years, with most patients presenting in the sixth decade. The time from first symptoms to the diagnosis ranged from a few days to 5 months. In the majority of patients, the leading symptoms were: headaches, motor weakness, aphasia and memory disturbance. Initial diagnosis was based on MR in 3 patients, CT in 7 and on both CT and MR in 1 patient. The frontal lobe was the most common site of involvement. All the patients underwent surgery. The histological diagnosis was confirmed by immunohistochemical analysis using monoclonal antibodies: CD 20, CD3, CKMNF 116. In all cases, a B-cell type lymphoma was diagnosed. Radiotherapy was administered to 4 patients, 2 received chemotherapy and 1 received combined treatment. The median survival time so far is 17.6 months.