Cell activation in the hypothalamus after exposure to an antigen (based on c-fos gene expression)
Nosov, M.A.; Barabanova, S.V.; Glushikhina, M.S.; Kazakova, T.B.; Korneva, E.A.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 87(3): 331-340
2001
ISSN/ISBN: 0869-8139 PMID: 11386157 Document Number: 532264
Increase of the c-fos mRNA positive cells number was insignificant in 30 min. following activation of the rat hypothalamic structures with the tetanus toxoid (TT). Elevation of the c-fos mRNA positive cells number occurred in the hypothalamic' posterior (PHA), lateral (LHA), anterior (AHA), areas dorsomedial (DMH), and ventromedial (VMH) nuclei within 2 hours of the TT administration. In 6 hours the c-fos mRNA positive cells number decreased in PHA, LHA, DMH. The c-fos mRNA expression was stable in arquate and supraoptic hypothalamic nuclei following either the TT or saline administration.