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Expression of proenkephalin (PENK) mRNA in inflammatory leukocytes during experimental peritonitis in Swiss mice

Chadzinska, M.; Maj, M.; Scislowska-Czarnecka, A.; Przewłocka, B.; Plytycz, B.

Polish Journal of Pharmacology 53(6): 715-718

2001

ISSN/ISBN: 1230-6002
PMID: 11985352
Document Number: 532154
Zymosan- or thioglycollate-induced experimental peritoneal inflammation in mice may serve as a convenient model for investigations of involvement of opioid peptides derived from exudatory leukocytes in the inflammatory processes. During peritonitis, the influx of neutrophils and monocytes/macrophages correlated with a sequential appearance of proinflammatory cytokines (IL-1beta and TNFalpha). After both kinds of stimulation, the expression of PENK mRNA was much higher in exudatory peritoneal leukocytes than its basal level in steady state.

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