Oral contraceptives and cholestasis
Richter, J.; Ohlen, J.; Balletshofer, C.; Pause, H.
Verhandlungen der Deutschen Gesellschaft für Innere Medizin 78: 1538-1539
1972
ISSN/ISBN: 0070-4067 PMID: 4665603 Document Number: 53176
54 fertile women taking oral contraceptives for up to 4 1/2 years were compared with a similar unmedicated group. Statistically the groups differed significantly, with leucin amino peptidase and gamma-glutamyl transpeptidase significantly elevated in the 1st group. 11 other women on the same oral contraceptive were examined and found to have increased alkaline liver/cholan-phospho-estrase activity along with a decrease in iso-enzymes of ossarous origin. This type of enzyme activity is characteristic of a mild cholesteric reaction of the liver, and healthy women taking oral contraceptives almost regularly develop this particular serum enzyme constellation.
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