Hypoxia as a modality to correct disturbances in bone oxygen uptake at various static-kinetic conditions
Berezovskiĭ, V.A.; Nosar', V.I.; Khasabova, I.A.; Nazaruk, I.A.
Aviakosmicheskaia i Ekologicheskaia Meditsina 35(5): 37-40
2001
ISSN/ISBN: 0233-528X PMID: 11840869 Document Number: 531332
Osteodystrophy models consisted in removing weight loading from hind limbs and rats' immobilization; disturbances in bone oxygen uptake were quelled by induced gaseous environment with low PO2. Unloading of the hind limbs for 28 days was found to decrease oxygen uptake by fragments of the iliac bone, and oxygen pressure in m. gastrocnemius. These parameters were unchanged in atmosphere with 12% of oxygen. Motor restraint of rats in hypoxic atmosphere leads to less marked reductions in oxygen demand in iliac fragments and oxygen pressure in m. gastrocnemius as compared with breathing ambient air.