Mutation BRCA1 gene in 186 breast cancer patients
Lai, C.; Jiang, Z.; Song, S.
Zhonghua Zhong Liu Za Zhi 23(6): 483-485
2001
ISSN/ISBN: 0253-3766 PMID: 11859716 Document Number: 531117
To analysis the mutation of BRCA1 gene in 186 breast cancer patients. Polymerase chain reaction-single stranded conformational polymorphism (PCR-SSCP) and sequential were used in this analysis. 13/186 of patients showed mutation which comprised 7% of the total number of patients. In 8 patients, the mutation was observed in the intron splicing region and in 5 patients, the mutation was on the exon. Mutation analysis of BRCA1 gene is helpful in the determination of developmental potential, early diagnosis and gene therapy for breast cancer.