Thienopyrimidine derivatives prevent cartilage destruction in articular disease
Cardile APV; Santagati, A.; Gentile, B.
Farmaco 56(12): 959-964
2001
ISSN/ISBN: 0014-827X PMID: 11829117 Document Number: 530910
The effects of a series of thienopyrimidine derivatives on the prevention of cartilage destruction in articular disease were investigated. Anti-degenerative activity was assayed on culture of nasal pig cartilage in the presence or in the absence of interleukin 1beta (IL-1beta). The amount of glycosaminoglycans (GAGs) and the production of nitric oxide (NO) in the culture medium were determined. Some thienopyrimidine derivatives, in the presence of IL-beta, blocked the cartilage breakdown by inhibiting both the NO production and GAGs release in a dose-dependent manner.