Experimental evaluation of efficacy of Lactobacilli in prophylaxis and treatment of cholera
Bardykh, I.D.; Krylikov, V.D.; Mazrukho, B.L.; Ryzhko, I.V.; Moskvitina, E.A.; Tsuraeva, R.I.; Vinokur, N.I.; Drobotkovskaia, N.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2: 68-71
2001
ISSN/ISBN: 0372-9311 PMID: 11548265 Document Number: 530244
Investigations on experimental models of cholera ("sealed" mice and suckling rabbits) demonstrated that previous daily oral administration of the ferment culture of Lactobacillus acidophilus BKM B-2020[symbol: see text] in a dose of 3.0 x 10(8) microbial cells/ml daily for 5-7 days prevented to the development of Vibrio cholerae infection. The curative effect observed after 3 administrations of lactobacilli within 48 hours after infection with V. cholerae was registered in 50% of cases. This strain of lactobacilli was found to be suitable for use as the basis component of probiotic, an additional remedy for the prophylaxis and treatment of cholera.