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DNA vaccine

Sato, Y.

Rinsho Byori. Japanese Journal of Clinical Pathology 49(7): 669-672

2001

ISSN/ISBN: 0047-1860
PMID: 11519128
Document Number: 529591
DNA vaccine involves the injection of plasmid DNA encoding an antigen under the control of an eukaryotic promoter, and results in cellular and humoral immune responses to the plasmid DNA-encoded antigen. The immune response induced by DNA vaccine usually has a T-helper-1(Th1) bias through a potent Th1-promoting adjuvant effect of immunostimulatory DNA sequences with CpG motifs present in plasmid DNA. It has been demonstrated that volunteers who were vaccinated with plasmid DNA encoding a malaria protein or a human immunodeficiency virus protein developed antigen-specific, human leukocyte antigen(HLA)-restricted, CD8+ cytotoxic T lymphocytes(CTLs) The demonstration in humans of the induction of CD8+ CTLs by DNA vaccines, including CTLs, provides a foundation for further clinical application of this potentially revolutionary vaccine technology.

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