Current therapeutic approaches of neurologic damage in neonatal asphyxia
Marconi, M.
Annali Dell'istituto Superiore di Sanita 37(4): 483-496
2001
ISSN/ISBN: 0021-2571 PMID: 12046218 Document Number: 529361
Perinatal hypoxiaischaemia is a major cause of mortality and neurological sequelae in term newborn. Modulation of mechanisms leading to brain cell death, in the so-called therapeutic window, may reduce apoptosis and necrosis. Oxidative stress and newborn resuscitation, early postnatal pharmacological treatment and hypothermic neuroprotection are described. Additional controlled prospective trials are warranted on newborns. A combination of neuroprotective agents with synergistic effects could represent a potential treatment strategy.