Phospholipase C negatively regulates tyrosine phosphorylation of EGF receptor in A-431 cells
Evdonin, A.L.; Leonov, A.N.; Tsupkina, N.V.; Medvedeva, N.D.
Tsitologiia 43(8): 797-802
2001
ISSN/ISBN: 0041-3771 PMID: 11601396 Document Number: 527984
It is known that EGF induces tyrosine phosphorylation and internalization of the EGF receptor in A-431 cells. U73122, an inhibitor of phospholipase C, induces tyrosine phosphorylation of the EGF receptor and its association with phospholipase C still in nonstimulated cells. In U73122 treated cells EGF exerted no effect on these processes. Receptor-mediated endocytosis was not observed in A-431 cells treated with U73122. The reorganization of actin cytoskeleton was detected in U73122 cells.