Corneal opacifications in a low high density lipoprotein syndrome: suspicion of fish eye disease: a case report
De Smedt, M.; Van Ginderdeuren, R.; De Vos, R.; Mertens, A.; Muls, E.; Foets, B.
Bulletin de la Societe Belge d'Ophtalmologie 2001(282): 25-30
2001
ISSN/ISBN: 0081-0746 PMID: 12455137 Document Number: 527534
A 49 year old patient with progressive massive bilateral corneal opacifications associated with a HDL (high-density-lipoprotein) deficiency is described. The opacifications started at the age of twenty and progressed slowly. They were found diffusely over the cornea, though more in the corneal periphery. A penetrating keratoplasty at the right eye was performed. The diagnosis of Fish Eye Disease was put forward on the basis of the ophthalmological, clinical, biochemical and pathological appearance. After 2 year follow-up, the graft was clear. The final distance and near vision of the right eye was 8/10 and Snellen 1 respectively.