Unbalanced distribution of urinary human chorionic gonadotropin subunits in lung and breast cancer cases
D.C.stro Bernas, G.; Garcia, I.J.
Acta Manilana 45: 7-11
1997
ISSN/ISBN: 0567-7688 Document Number: 526836
The alpha and beta subunits of human chorionic gonadotropin (hCG) from 167 urine samples of patients clinically diagnosed to have lung and breast cancers and 70 urine samples of non-pregnant normal and pregnant subjects were separated using ion-exchange chromatography. Determination of the autocrine hormone in the urine samples from non-small cell lung carcinoma cases revealed that 69% have significantly elevated alpha subunits (p<0.05). Of the 19 small cell lung cancer cases screened, 26% showed elevated alpha peaks. Of the 50 breast cancer cases screened, 64% have significantly elevated alpha peaks (p<0.05). In non-pregnant normal and pregnant urine samples, 66% and 90% respectively, elevated beta peaks were observed.