Effect of omeprazole on gallbladder contraction in humans
Kapicioglu, S.; Baki, A.H.; Arslan, M.; Cetiner, M.; Cihanyurdu, N.
Hepato-Gastroenterology 47(32): 346-348
2000
ISSN/ISBN: 0172-6390 PMID: 10791186 Document Number: 526103
Background/Aims: Omeprazole causes hypergastrinemia because of the effects of prolonged complete suppression of acid secretion and also gastrin has an excitatory effect on gallbladder contraction. Therefore, we investigated the meal-induced gallbladder emptying in healthy subjects receiving omeprazole and compared them to controls. Methodology: Twenty healthy volunteers participated in this study. Gallbladder volume was measured by ultrasonography. After basal measurement, the volunteers received saline intravenously (i.v) 2cc (no:10) or omeprazole 20 mg i.v (no:10). After 15min the gallbladder volume was scanned at 15 min intervals for 60 min for each of the subjects. At the end of the period, all the subjects received a standard test meal (ensure 250cal/250mL), after 1 hour the gallbladder volumes were rescanned at 15min periods for 60min. Results: Mean gallbladder volume in the omeprazole group was not significantly different during a 45min period as compared to the baseline value. The residual gallbladder volume at the end of the 15th minute (43.9+-5.6mL), 30th minute (45.4+-5.9mL), 45th minute (40.5+-6.1mL) and 60th minute (40.5+-6.1mL) showed no significant differences in both the omeprazole group and the controls. Mean gallbladder volumes of both groups after meal intake were significantly lower during the 1-hour period as compared to the baseline value (P<0.05). The mean volumes did not show any significant differences between the omeprazole group and the control subjects. Conclusions: Omeprazole did not change the gallbladder volume during fasting and the post-prandial period as compared to the control group.