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Interleukin-18: biological properties and clinical implications

Lebel-Binay, S.; Berger, A.; Zinzindohoué, F.; Cugnenc, P.; Thiounn, N.; Fridman, W.H.; Pagès, F.

European Cytokine Network 11(1): 15-26

2000

ISSN/ISBN: 1148-5493
PMID: 10705295
Document Number: 525897
IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure, processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role of IL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases.

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