Long-term action of vitamin D suppresses the estradiol-induced activity of erk-1 MAPK and proliferation of MCF-7 and LNCaP cancer cells
Liakhovich, A.V.; Aksenov, N.L.; Tuokhima, P.; Mikhel'son, V.M.
Tsitologiia 42(10): 977-982
2000
ISSN/ISBN: 0041-3771 PMID: 11200137 Document Number: 525377
A study was made of the influence of a long-term exposure of 1,25-dihydroxyvitamin D3 and 17 beta-estradiol on deactivation of MAP kinases in correlation with proliferation of cancer cells. The obtained results illustrate inhibition of cell growth after vitamin D treatment. Mechanisms of such an inhibition are discussed.
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