Differential diagnosis of oxyphilic (Hürthle cell) adenomas and carcinomas of the thyroid
Tret'iakova, M.S.; Bussolati, J.
Arkhiv Patologii 62(6): 14-18
2000
ISSN/ISBN: 0004-1955 PMID: 11198115 Document Number: 525010
Successful application of a double immunostaining of oxyphilic tumors with a specific antimitochondrial antibody and proliferative marker Ki-67 was made for the first time. Comparative study of proliferative activity did not show a statistically significant difference between Hurthle-cell adenomas and carcinomas. However, oxyphilic carcinomas had a statistically significant positive correlation between proliferative index and aggressive course of tumor, tendency to recurrence, high metastatic activity, tumor size, presence of necrosis and capsule penetration.