Twenty-four hour intraesophageal pH monitoring in children and adolescents with scleroderma and mixed connective tissue disease
Weber, P.; Ganser, G.; Frosch, M.; Roth, J.; Hülskamp, G.; Zimmer, K.P.
Journal of Rheumatology 27(11): 2692-2695
2000
ISSN/ISBN: 0315-162X PMID: 11093455 Document Number: 524177
Objective: To investigate esophageal dysmotility and gastroesophageal reflux, which are important, but often occult features of gastrointestinal (GI) involvement in children and adolescents with mixed connective tissue disease (MCTD) and scleroderma. Methods: We carried out intraesophageal 24 h pH monitoring of 14 patients with scleroderma and MCTD. Results: We observed an elevated reflux index in 64% of the patients. An increased number of reflux events was found in 85%. Reflux events > 5 min were noted in 50% of the patients, which is indicative of possible development of esophagitis. Only 3 patients presented clinical symptoms. Four of 5 patients with localized scleroderma revealed a pathological reflux index. We found no relationship between gastroesophageal reflux, age of patients, duration of disease, and Raynaud's phenomenon. Conclusion: GI involvement in children with scleroderma or MCTD is more frequent than clinical symptoms indicate. An active diagnostic investigation for GI dysmotility and gastroesophageal reflux is necessary to detect these complications.