Cerebrovascular circulation during blockade of angiotensin receptors
Adzhienko, L.M.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 86(1): 28-32
2000
ISSN/ISBN: 0869-8139 PMID: 10740833 Document Number: 523867
In experiments on anaesthetized rats, Losartan was found to cause an obvious decrease in the ABP in normotensive rats. The cerebral blood flow differed independence on cerebral vascular resistance and the ABP level. The autoregulation of the cerebral blood flow remained unaltered. In hypertensive rats Losartan caused a significant decrease in the ABP as compared with normotensive rats. A shift of lower limits of the cerebral blood flow autoregulation towards a lower ABP level, was observed.