The role of peptides in the cholinergic and adrenergic mechanisms of the regulation of gastric secretion
Korshak, O.L.; Kotsiuba, V.L.
Fiziolohichnyi Zhurnal 46(4): 8-16
2000
ISSN/ISBN: 2522-9028 PMID: 10997294 Document Number: 523269
With using pharmacological analysis of stimulation or blockage of enterocytes cholin- or adrenergic receptors chronic experiments on dogs with gastric fistulas were carried out to study the influence of peptides on gastric acid secretion stimulated by pentagastrin or histamine. The different peptides (met- and leu-enkephalins, substance P, angiotensins I and II, oxytocin, pentagastrin) and internal secretion hormones (insulin, glucagon) were infused parenterally under the stimulated gastric secretion. It is proposed the model of the peripheral link of neurohumoral regulation of gastric acid secretion in the stomach.