Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes
Jagodziński, P.P.; Trzeciak, W.H.
Folia Histochemica et Cytobiologica 38(1): 21-23
2000
ISSN/ISBN: 0239-8508 PMID: 10763120 Document Number: 523185
Different cytokine profiles allow to divide the CD4+ lymphocytes into Th1, Th2 and Th0 subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1 replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood lymphocytes of HIV-1 seronegative individuals and the density of CXCR4 receptors was determined by flow cytometry using antibodies directed against the CXCR4 receptor. Flow cytometric analysis revealed higher expression of the HIV-1 co-receptor CXCR4 on Th2 cells than on the Th1, which might explain better replication of HIV-1 viruses in the Th2 cells.