Synergistic efficacy of adenovirus-mediated bcl-Xs gene therapy and cisplatin in ovarian cancer cell
Wang, H.; Baker, V.V.
Zhonghua Fu Chan Ke Za Zhi 35(2): 94-97
2000
ISSN/ISBN: 0529-567X PMID: 11809108 Document Number: 522705
To observe the presence of synergistic efficacy between adenovirus-mediated bcl-Xs (Adv-bcl-Xs) gene therapy and cisplatin (CDDP) in ovarian cancer cell. NuTu-19 cells were infected by different titers of Adv-bcl-Xs and treated with CDDP in the meantime. Percentage of cell proliferation was measured by methyl thiazolyl tetrazolium and cell cycles were measured by flow cytometry 3 days later. Graphical representations of the statistical analyses for their interaction in tumor cells. The statistical results and Graphical representations of the statistical modeling showed that the synergistic antiproliferative activity was present (P < 0.01). There was synergistic efficacy between Adv-bcl-Xs gene and CDDP for the inhibition of ovarian cancer cell.