When disease insight is halting. II. the neurobiological underpinnings
Starmark, J.E.; Hellström, P.H.; Agren, H.
Lakartidningen 97(4): 328-331
2000
ISSN/ISBN: 0023-7205 PMID: 10684227 Document Number: 521913
This review examines the neurobiological underpinnings of impaired insight and awareness in psychosis. Crucial mainly dopaminergic pathways are discussed in relation to delusions and hallucinations. Thirty percent of psychotic patients with impaired insight will not respond to traditional neuroleptic drug treatment, and the possibility that multifocal brain etiology might underlie such cases is discussed. It is suggested that severe cases of thought process disorder in psychosis may result from such multifocal processes.