Cerebellar atrophy in an epileptic child: is it due to phenytoin?
Ahuja, S.R.; Karande, S.; Kulkarni, M.V.
Journal of Postgraduate Medicine 46(4): 278-279
2000
ISSN/ISBN: 0022-3859 PMID: 11435657 Document Number: 521636
A four and half year old epileptic child on phenytoin therapy since one year presented with signs of cerebellar dysfunction. Serum phenytoin level was high (33 mcg/ml) and computerised tomographic scan of the brain showed severe generalised cerebellar atrophy. The cerebellar signs represented drug over dosage and toxicity and persisted long after omission of phenytoin.