Connective tissue disease and other related rheumatic conditions among patients with finger and hand and temporomandibular joint prostheses in Denmark
Fryzek, J.P.; Mellemkjaer, L.; Friis, S.; McLaughlin, J.K.; Rosenthal, A.K.; Blot, W.J.; Olsen, J.H.
Journal of Rheumatology 27(6): 1434-1436
2000
ISSN/ISBN: 0315-162X PMID: 10852266 Document Number: 521451
Objective. To determine if finger and hand joint prostheses or temporomandibular joint (TMJ) implants may be involved in the initiation of specific connective tissue diseases (CTD), a nationwide cohort in Denmark was followed prospectively to evaluate rates of CTD after receiving these implants. Methods. Danish patients with finger and hand joint implants (n = 562) or TMJ implants (n = 351) were identified and followed for subsequent hospitalizations. Observed numbers of hospitalizations due to CTD were compared with expected numbers based on national CTD hospitalization rates. To avoid confounding by indication, patients with a hospital discharge diagnosis of a CTD prior to prosthetic surgery were excluded from the cohort. Results. After 4142 person-years of followup in the finger and hand joint cohort, 9 hospitalizations due to CTD were found (standard hospitalization rate (SHR) = 1.5; 95% CI 0.7-2.9). The TMJ cohort had 1500 person-years of followup and 2 hospitalizations due to CTD (SHR = 1.3; 95% CI 0.2-4.5). Conclusion. This is the first cohort study to examine the relations between these implants and CTD. Although the number of events was small, this systematic national study revealed no significant or large increase in risk of CTD after finger and hand joint implants or TMJ implants.