Relationship between parameters of hemostasis and manifestations of the metabolic syndrome in men with mild and moderate hypertension
Ratnikova, L.A.; Metel'skaia, V.A.; Mamedov, M.N.; Olfer'ev, A.M.; Perova, N.V.
Terapevticheskii Arkhiv 72(9): 13-16
2000
ISSN/ISBN: 0040-3660 PMID: 11076408 Document Number: 521282
To study the relationship between major hemostasis parameters and hypertriglyceridemia with or without insulin resistance/hyperinsulinemia in men suffering from mild or moderate arterial hypertension. Major hemostasis parameters including fibrinogen level, coagulation factor VII activity and fibrinolytic activity were analysed in groups of men with moderate or mild AH who had normal or elevated triglycerides level regarding presence or absence of insulin resistance/hyperinsulinemia. High factor VII activity was found in both groups with insulin resistance irrespective of their triglycerides level. Patients with insulin resistance combined with hypertriglyceridemia had low fibrinolytic activity. In men with metabolic syndrome components insulin resistance is accompanied with activation of coagulation external pathway, whereas combination of insulin resistance with hypertriglyceridemia was associated with hypofibrinolysis.